Please use this identifier to cite or link to this item:
|Title:||Tailored albumin-based copolymers for receptor-mediated delivery of perylenediimide guest molecules|
Human serum albumin
|Citation:||Eisele, K., Gropeanu, R., Musante, A., Glasser, G., Li, C., Muellen, K., Weil, T. (2010-09-01). Tailored albumin-based copolymers for receptor-mediated delivery of perylenediimide guest molecules. Macromolecular Rapid Communications 31 (17) : 1501-1508. ScholarBank@NUS Repository. https://doi.org/10.1002/marc.201000176|
|Abstract:||Figure Presented The synthesis of a novel and multifunctional copolymer based on a human serum albumin backbone bearing several folic acid as well as PEO groups was presented. In solution, this sidechain copolymer adopts a globular architecture and about five molecules of the waterinsoluble chromophore PDI were successfully incorporated into these micelles for receptor-mediated cell uptake investigations. A significant uptake of these bioconjugates via receptor-mediated endocytosis was detected for cells expressing folic acid receptors in the cell membrane. These novel albumin-based copolymers could serve as efficient and biocompatible carrier systems facilitating the directed delivery of lipophilic drug molecules into cancer cells and they allow investigating vesicle formation and trafficking even at the single molecule level. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.|
|Source Title:||Macromolecular Rapid Communications|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 17, 2019
WEB OF SCIENCETM
checked on Jan 9, 2019
checked on Dec 7, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.