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Title: Synthesis of chiral butenolides using amino-thiocarbamate-catalyzed asymmetric bromolactonization
Authors: Tan, C.K.
Er, J.C.
Yeung, Y.-Y. 
Keywords: Asymmetric reaction
Lewis base
Issue Date: 5-Feb-2014
Citation: Tan, C.K., Er, J.C., Yeung, Y.-Y. (2014-02-05). Synthesis of chiral butenolides using amino-thiocarbamate-catalyzed asymmetric bromolactonization. Tetrahedron Letters 55 (6) : 1243-1246. ScholarBank@NUS Repository.
Abstract: The asymmetric cyclization of 4,4-disubstituted 3-butenoic acids is studied. Amino-thiocarbamates are used as the catalysts and N-bromosuccinimide is used as the stoichiometric halogen source. The resulting γ-butanolide products are readily converted into the corresponding γ-butenolides (up to 58% ee) derivatives in one-pot. © 2014 Elsevier Ltd. All rights reserved.
Source Title: Tetrahedron Letters
ISSN: 00404039
DOI: 10.1016/j.tetlet.2014.01.009
Appears in Collections:Staff Publications

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