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https://doi.org/10.1016/j.tetlet.2014.01.009
| Title: | Synthesis of chiral butenolides using amino-thiocarbamate-catalyzed asymmetric bromolactonization | Authors: | Tan, C.K. Er, J.C. Yeung, Y.-Y. |
Keywords: | Asymmetric reaction Bromolactonization Catalysis Lewis base |
Issue Date: | 5-Feb-2014 | Citation: | Tan, C.K., Er, J.C., Yeung, Y.-Y. (2014-02-05). Synthesis of chiral butenolides using amino-thiocarbamate-catalyzed asymmetric bromolactonization. Tetrahedron Letters 55 (6) : 1243-1246. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tetlet.2014.01.009 | Abstract: | The asymmetric cyclization of 4,4-disubstituted 3-butenoic acids is studied. Amino-thiocarbamates are used as the catalysts and N-bromosuccinimide is used as the stoichiometric halogen source. The resulting γ-butanolide products are readily converted into the corresponding γ-butenolides (up to 58% ee) derivatives in one-pot. © 2014 Elsevier Ltd. All rights reserved. | Source Title: | Tetrahedron Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/95116 | ISSN: | 00404039 | DOI: | 10.1016/j.tetlet.2014.01.009 |
| Appears in Collections: | Staff Publications |
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