Hydroethidine as a probe for measuring superoxide formation rates during air oxidation of myricetin and quercetin

Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tetlet.2011.08.044

Title:	Hydroethidine as a probe for measuring superoxide formation rates during air oxidation of myricetin and quercetin
Authors:	Quek, Y.L. Huang, D.
Keywords:	Fluorescent probe Hydroethidine Myricetin Pro-oxidant Superoxide
Issue Date:	12-Oct-2011
Citation:	Quek, Y.L., Huang, D. (2011-10-12). Hydroethidine as a probe for measuring superoxide formation rates during air oxidation of myricetin and quercetin. Tetrahedron Letters 52 (41) : 5384-5387. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tetlet.2011.08.044
Abstract:	In the presence of the flavonols myricetin and quercetin, oxidation of hydroethidine (HE) by superoxide yielded ethidium (E+) instead of 2-hydroxyethidium (2-OH-E+). As a known pro-oxidant, myricetin alone was also found to be able to catalyze air oxidation of HE yielding exclusively E+. The reaction is inhibited by added superoxide dismutase, suggesting that superoxide is involved in the rate limiting step of the oxidation. © 2011 Elsevier Ltd. All rights reserved.
Source Title:	Tetrahedron Letters
URI:	http://scholarbank.nus.edu.sg/handle/10635/93976
ISSN:	00404039
DOI:	10.1016/j.tetlet.2011.08.044
Appears in Collections:	Staff Publications

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