Please use this identifier to cite or link to this item:
https://doi.org/10.1055/s-0030-1250673
Title: | Cytotoxic triterpenoids and steroids from the bark of Melia azedarach | Authors: | Wu, S.-B. Bao, Q.-Y. Wang, W.-X. Zhao, Y. Xia, G. Zhao, Z. Zeng, H. Hu, J.-F. |
Keywords: | cytotoxicity Melia azedarach Meliaceae steroids triterpenoids |
Issue Date: | 2011 | Citation: | Wu, S.-B., Bao, Q.-Y., Wang, W.-X., Zhao, Y., Xia, G., Zhao, Z., Zeng, H., Hu, J.-F. (2011). Cytotoxic triterpenoids and steroids from the bark of Melia azedarach. Planta Medica 77 (9) : 922-928. ScholarBank@NUS Repository. https://doi.org/10.1055/s-0030-1250673 | Abstract: | Two new triterpenoids (1, 2) and two new steroids (3, 4) along with twelve related known compounds (5-16) were isolated from the bark of Melia azedarach. The new structures were elucidated by means of spectroscopic methods and molecular modeling studies and found to be 21,24-cycloeupha-7-ene-3β, 16β,21α,25-tetrol (1), 3β-acetoxy-12β-hydroxy-eupha-7,24- dien-21,16β-olide (2), 29-hydroperoxy-stigmasta-7,24(28)E-dien-3β-ol (3), and 24ξ-hydroperoxy-24-vinyl-lathosterol (4). All isolated compounds were tested for their cytotoxic activity against three human cancer cell lines (A549, H460, HGC27) using the CellTiter Glo™ luminescent cell viability assay. Among them, compounds 2-4, 24ξ-hydroperoxy-24-vinyl-cholesterol (6), kulinone (7), meliastatin 3 (8), 3-oxo-olean-12-en-28-oic acid (10), and (22E,24S)-5α,8α-epidioxy-24-methyl-cholesta-6,22-dien-3β-ol (12) were found to have cytotoxic effects, with IC50 values of 5.6-21.2μg/mL. © Georg Thieme Verlag KG Stuttgart. | Source Title: | Planta Medica | URI: | http://scholarbank.nus.edu.sg/handle/10635/93519 | ISSN: | 00320943 | DOI: | 10.1055/s-0030-1250673 |
Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
SCOPUSTM
Citations
46
checked on Jan 31, 2023
WEB OF SCIENCETM
Citations
44
checked on Jan 31, 2023
Page view(s)
140
checked on Feb 2, 2023
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.