Please use this identifier to cite or link to this item:
https://doi.org/10.1055/s-0030-1250673
| DC Field | Value | |
|---|---|---|
| dc.title | Cytotoxic triterpenoids and steroids from the bark of Melia azedarach | |
| dc.contributor.author | Wu, S.-B. | |
| dc.contributor.author | Bao, Q.-Y. | |
| dc.contributor.author | Wang, W.-X. | |
| dc.contributor.author | Zhao, Y. | |
| dc.contributor.author | Xia, G. | |
| dc.contributor.author | Zhao, Z. | |
| dc.contributor.author | Zeng, H. | |
| dc.contributor.author | Hu, J.-F. | |
| dc.date.accessioned | 2014-10-16T08:25:15Z | |
| dc.date.available | 2014-10-16T08:25:15Z | |
| dc.date.issued | 2011 | |
| dc.identifier.citation | Wu, S.-B., Bao, Q.-Y., Wang, W.-X., Zhao, Y., Xia, G., Zhao, Z., Zeng, H., Hu, J.-F. (2011). Cytotoxic triterpenoids and steroids from the bark of Melia azedarach. Planta Medica 77 (9) : 922-928. ScholarBank@NUS Repository. https://doi.org/10.1055/s-0030-1250673 | |
| dc.identifier.issn | 00320943 | |
| dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/93519 | |
| dc.description.abstract | Two new triterpenoids (1, 2) and two new steroids (3, 4) along with twelve related known compounds (5-16) were isolated from the bark of Melia azedarach. The new structures were elucidated by means of spectroscopic methods and molecular modeling studies and found to be 21,24-cycloeupha-7-ene-3β, 16β,21α,25-tetrol (1), 3β-acetoxy-12β-hydroxy-eupha-7,24- dien-21,16β-olide (2), 29-hydroperoxy-stigmasta-7,24(28)E-dien-3β-ol (3), and 24ξ-hydroperoxy-24-vinyl-lathosterol (4). All isolated compounds were tested for their cytotoxic activity against three human cancer cell lines (A549, H460, HGC27) using the CellTiter Glo™ luminescent cell viability assay. Among them, compounds 2-4, 24ξ-hydroperoxy-24-vinyl-cholesterol (6), kulinone (7), meliastatin 3 (8), 3-oxo-olean-12-en-28-oic acid (10), and (22E,24S)-5α,8α-epidioxy-24-methyl-cholesta-6,22-dien-3β-ol (12) were found to have cytotoxic effects, with IC50 values of 5.6-21.2μg/mL. © Georg Thieme Verlag KG Stuttgart. | |
| dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1055/s-0030-1250673 | |
| dc.source | Scopus | |
| dc.subject | cytotoxicity | |
| dc.subject | Melia azedarach | |
| dc.subject | Meliaceae | |
| dc.subject | steroids | |
| dc.subject | triterpenoids | |
| dc.type | Article | |
| dc.contributor.department | CHEMISTRY | |
| dc.description.doi | 10.1055/s-0030-1250673 | |
| dc.description.sourcetitle | Planta Medica | |
| dc.description.volume | 77 | |
| dc.description.issue | 9 | |
| dc.description.page | 922-928 | |
| dc.description.coden | PLMEA | |
| dc.identifier.isiut | 000292028900008 | |
| Appears in Collections: | Staff Publications | |
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