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Title: Binding studies on modified vancomycin
Authors: Ang, S.-G. 
Peh, Y.-K.
Issue Date: 1997
Citation: Ang, S.-G.,Peh, Y.-K. (1997). Binding studies on modified vancomycin. Australian Journal of Chemistry 50 (1) : 31-34. ScholarBank@NUS Repository.
Abstract: Binding studies were carried out on a vancomycin derivative to examine its potential bactericidal activity. Of particular interest was the effect of dimethylation of the amino group at the N-terminus of vancomycin on the binding ability of the antibiotic to bacterial cell-wall peptide analogues, namely Ac-D-Ala-D-Ala and Ac2-L-Lys-D-Ala-D-Ala. Reductive methylation was carried out with sodium cyanoborohydride and formaldehyde, and the binding constants of the vancomycin derivative with the peptides were measured by ultraviolet difference spectroscopy.
Source Title: Australian Journal of Chemistry
ISSN: 00049425
Appears in Collections:Staff Publications

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