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|Title:||Binding studies on modified vancomycin|
|Authors:||Ang, S.-G. |
|Source:||Ang, S.-G.,Peh, Y.-K. (1997). Binding studies on modified vancomycin. Australian Journal of Chemistry 50 (1) : 31-34. ScholarBank@NUS Repository.|
|Abstract:||Binding studies were carried out on a vancomycin derivative to examine its potential bactericidal activity. Of particular interest was the effect of dimethylation of the amino group at the N-terminus of vancomycin on the binding ability of the antibiotic to bacterial cell-wall peptide analogues, namely Ac-D-Ala-D-Ala and Ac2-L-Lys-D-Ala-D-Ala. Reductive methylation was carried out with sodium cyanoborohydride and formaldehyde, and the binding constants of the vancomycin derivative with the peptides were measured by ultraviolet difference spectroscopy.|
|Source Title:||Australian Journal of Chemistry|
|Appears in Collections:||Staff Publications|
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