Please use this identifier to cite or link to this item: https://doi.org/10.1021/np960165e
Title: Anti-HIV triterpene acids from Geum japonicum
Authors: Xu, H.-X. 
Zeng, F.-Q.
Wan, M.
Sim, K.-Y. 
Issue Date: Jul-1996
Citation: Xu, H.-X., Zeng, F.-Q., Wan, M., Sim, K.-Y. (1996-07). Anti-HIV triterpene acids from Geum japonicum. Journal of Natural Products 59 (7) : 643-645. ScholarBank@NUS Repository. https://doi.org/10.1021/np960165e
Abstract: The methanol extract from the whole plant of Geum japonicum was found to inhibit the human immunodeficiency virus (HIV-1) protease. Through bioassay- directed fractionation of the extract, a new triterpene acid along with five known triterpene acids, ursolic acid, epipomolic acid, maslinic acid, euscaphic acid, and tormentic acid, were isolated. The structure of the new compound was determined by spectral means including 1H-1H COSY, HMQC, HMBC, and NOE experiments to be 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid (1). Of these compounds, 1, ursolic acid, and maslinic acid showed potent inhibitory activity against HIV-1 protease.
Source Title: Journal of Natural Products
URI: http://scholarbank.nus.edu.sg/handle/10635/93115
ISSN: 01633864
DOI: 10.1021/np960165e
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