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Please use this identifier to cite or link to this item: https://doi.org/10.1021/np960165e
DC FieldValue
dc.titleAnti-HIV triterpene acids from Geum japonicum
dc.contributor.authorXu, H.-X.
dc.contributor.authorZeng, F.-Q.
dc.contributor.authorWan, M.
dc.contributor.authorSim, K.-Y.
dc.date.accessioned2014-10-16T08:20:34Z
dc.date.available2014-10-16T08:20:34Z
dc.date.issued1996-07
dc.identifier.citationXu, H.-X., Zeng, F.-Q., Wan, M., Sim, K.-Y. (1996-07). Anti-HIV triterpene acids from Geum japonicum. Journal of Natural Products 59 (7) : 643-645. ScholarBank@NUS Repository. https://doi.org/10.1021/np960165e
dc.identifier.issn01633864
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/93115
dc.description.abstractThe methanol extract from the whole plant of Geum japonicum was found to inhibit the human immunodeficiency virus (HIV-1) protease. Through bioassay- directed fractionation of the extract, a new triterpene acid along with five known triterpene acids, ursolic acid, epipomolic acid, maslinic acid, euscaphic acid, and tormentic acid, were isolated. The structure of the new compound was determined by spectral means including 1H-1H COSY, HMQC, HMBC, and NOE experiments to be 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid (1). Of these compounds, 1, ursolic acid, and maslinic acid showed potent inhibitory activity against HIV-1 protease.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/np960165e
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1021/np960165e
dc.description.sourcetitleJournal of Natural Products
dc.description.volume59
dc.description.issue7
dc.description.page643-645
dc.description.codenJNPRD
dc.identifier.isiutA1996UZ99400001
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