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Title: Hyperbranched conjugated polyelectrolyte for dual-modality fluorescence and magnetic resonance cancer imaging
Authors: Ding, D. 
Wang, G.
Liu, J.
Li, K.
Pu, K.-Y. 
Hu, Y.
Ng, J.C.Y.
Tang, B.Z.
Liu, B. 
Keywords: conjugated polyelectrolytes
fluorescence imaging
hyperbranched polymers
in vivo imaging
magnetic resonance imaging
Issue Date: 19-Nov-2012
Citation: Ding, D., Wang, G., Liu, J., Li, K., Pu, K.-Y., Hu, Y., Ng, J.C.Y., Tang, B.Z., Liu, B. (2012-11-19). Hyperbranched conjugated polyelectrolyte for dual-modality fluorescence and magnetic resonance cancer imaging. Small 8 (22) : 3523-3530. ScholarBank@NUS Repository.
Abstract: Herein is reported the synthesis of gadolinium ion (Gd(III))-chelated hyperbranched conjugated polyelectrolyte (HCPE-Gd) and its application in fluorescence and magnetic resonance (MR) dual imaging in live animals. The synthesized HCPE-Gd forms nanospheres with an average diameter of ∼42 nm measured by laser light scattering and a quantum yield of 10% in aqueous solution. The absorption spectrum of HCPE-Gd has two maxima at 318 and 417 nm, and its photoluminescence maximum centers at 591 nm. Confocal laser scanning microscopy studies indicate that the HCPE-Gd is internalized in MCF-7 cancer cell cytoplasm with good photostability and low cytotoxicity. Further fluorescence and MR imaging studies on hepatoma H22 tumor-bearing mouse model reveal that HCPE-Gd can serve as an efficient optical/MR dual-modal imaging nanoprobe for in vivo cancer diagnosis. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Small
ISSN: 16136810
DOI: 10.1002/smll.201201216
Appears in Collections:Staff Publications

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