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|Title:||Combinatorial treatment of photothermal therapy using gold nanoshells with conventional photodynamic therapy to improve treatment efficacy: An in vitro study||Authors:||Kah, J.C.Y.
|Keywords:||Epidermal growth factor receptor (EGFR)
Photodynamic therapy (PDT)
Photothermal therapy (PTT)
|Issue Date:||Oct-2008||Citation:||Kah, J.C.Y., Wan, R.C.Y., Wong, K.Y., Mhaisalkar, S., Sheppard, C.J.R., Olivo, M. (2008-10). Combinatorial treatment of photothermal therapy using gold nanoshells with conventional photodynamic therapy to improve treatment efficacy: An in vitro study. Lasers in Surgery and Medicine 40 (8) : 584-589. ScholarBank@NUS Repository. https://doi.org/10.1002/lsm.20674||Abstract:||Background and Objective: Both photodynamic (PDT) and photothermal (PTT) therapy have proven to be effective treatment strategies for cancer, but the approach of combining them into a single treatment modality may offer better treatment efficacy. We compare the treatment efficacy of such combined treatment with the individual treatment. Study Design/Materials and Methods: We perform the individual PDT, PTT and combined treatment under selected in vitro condition with our low light dose of 1.44 J/cm2 and compare their cell viability using crystal fast violet assay. Results: Compared to PDT and PTT alone which can reduce cell viability to 30.9% and 44.0% respectively, the combined treatment under a single irradiation can further reduce the cell viability to 17.5%. Conclusion: A combined PDT and PTT treatment appears to be a more effective treatment strategy compared to conventional PDT or emerging PTT treatment. © 2008 Wiley-Liss, Inc.||Source Title:||Lasers in Surgery and Medicine||URI:||http://scholarbank.nus.edu.sg/handle/10635/87734||ISSN:||01968092||DOI:||10.1002/lsm.20674|
|Appears in Collections:||Staff Publications|
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