Please use this identifier to cite or link to this item: https://doi.org/10.1002/lsm.20674
Title: Combinatorial treatment of photothermal therapy using gold nanoshells with conventional photodynamic therapy to improve treatment efficacy: An in vitro study
Authors: Kah, J.C.Y. 
Wan, R.C.Y.
Wong, K.Y.
Mhaisalkar, S.
Sheppard, C.J.R. 
Olivo, M. 
Keywords: Epidermal growth factor receptor (EGFR)
Gold nanoshells
Hypericin
Photodynamic therapy (PDT)
Photothermal therapy (PTT)
Issue Date: Oct-2008
Source: Kah, J.C.Y., Wan, R.C.Y., Wong, K.Y., Mhaisalkar, S., Sheppard, C.J.R., Olivo, M. (2008-10). Combinatorial treatment of photothermal therapy using gold nanoshells with conventional photodynamic therapy to improve treatment efficacy: An in vitro study. Lasers in Surgery and Medicine 40 (8) : 584-589. ScholarBank@NUS Repository. https://doi.org/10.1002/lsm.20674
Abstract: Background and Objective: Both photodynamic (PDT) and photothermal (PTT) therapy have proven to be effective treatment strategies for cancer, but the approach of combining them into a single treatment modality may offer better treatment efficacy. We compare the treatment efficacy of such combined treatment with the individual treatment. Study Design/Materials and Methods: We perform the individual PDT, PTT and combined treatment under selected in vitro condition with our low light dose of 1.44 J/cm2 and compare their cell viability using crystal fast violet assay. Results: Compared to PDT and PTT alone which can reduce cell viability to 30.9% and 44.0% respectively, the combined treatment under a single irradiation can further reduce the cell viability to 17.5%. Conclusion: A combined PDT and PTT treatment appears to be a more effective treatment strategy compared to conventional PDT or emerging PTT treatment. © 2008 Wiley-Liss, Inc.
Source Title: Lasers in Surgery and Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/87734
ISSN: 01968092
DOI: 10.1002/lsm.20674
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