Please use this identifier to cite or link to this item:
|Title:||Diversity-driven chemical probe development for biomolecules: Beyond hypothesis-driven approach||Authors:||Kang, N.-Y.
|Issue Date:||Jul-2011||Citation:||Kang, N.-Y., Ha, H.-H., Yun, S.-W., Yu, Y.H., Chang, Y.-T. (2011-07). Diversity-driven chemical probe development for biomolecules: Beyond hypothesis-driven approach. Chemical Society Reviews 40 (7) : 3613-3626. ScholarBank@NUS Repository. https://doi.org/10.1039/c0cs00172d||Abstract:||Bioprobes are indispensable tools for biological study and clinical diagnosis. A conventional strategy for probe development is hypothesis-driven approach based on known molecular mechanisms of recognition for individual analytes. However, even the most sophisticated rational design does not always guarantee the applicability of probes in complex biological systems, therefore the efficiency and scope of probe development has been intrinsically limited. Diversity-driven approach is a rapidly emerging alternative and has been employed for the development of new probes even in the absence of the knowledge about target recognition mechanism. This tutorial review summarizes the recent advances in probe development along with conceptual advantages and perspectives of the diversity-driven approach. © 2011 The Royal Society of Chemistry.||Source Title:||Chemical Society Reviews||URI:||http://scholarbank.nus.edu.sg/handle/10635/77599||ISSN:||03060012||DOI:||10.1039/c0cs00172d|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 27, 2020
WEB OF SCIENCETM
checked on Mar 19, 2020
checked on Mar 30, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.