Please use this identifier to cite or link to this item: https://doi.org/10.1039/c0cs00172d
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dc.titleDiversity-driven chemical probe development for biomolecules: Beyond hypothesis-driven approach
dc.contributor.authorKang, N.-Y.
dc.contributor.authorHa, H.-H.
dc.contributor.authorYun, S.-W.
dc.contributor.authorYu, Y.H.
dc.contributor.authorChang, Y.-T.
dc.date.accessioned2014-06-23T05:57:05Z
dc.date.available2014-06-23T05:57:05Z
dc.date.issued2011-07
dc.identifier.citationKang, N.-Y., Ha, H.-H., Yun, S.-W., Yu, Y.H., Chang, Y.-T. (2011-07). Diversity-driven chemical probe development for biomolecules: Beyond hypothesis-driven approach. Chemical Society Reviews 40 (7) : 3613-3626. ScholarBank@NUS Repository. https://doi.org/10.1039/c0cs00172d
dc.identifier.issn03060012
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/77599
dc.description.abstractBioprobes are indispensable tools for biological study and clinical diagnosis. A conventional strategy for probe development is hypothesis-driven approach based on known molecular mechanisms of recognition for individual analytes. However, even the most sophisticated rational design does not always guarantee the applicability of probes in complex biological systems, therefore the efficiency and scope of probe development has been intrinsically limited. Diversity-driven approach is a rapidly emerging alternative and has been employed for the development of new probes even in the absence of the knowledge about target recognition mechanism. This tutorial review summarizes the recent advances in probe development along with conceptual advantages and perspectives of the diversity-driven approach. © 2011 The Royal Society of Chemistry.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1039/c0cs00172d
dc.sourceScopus
dc.typeReview
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1039/c0cs00172d
dc.description.sourcetitleChemical Society Reviews
dc.description.volume40
dc.description.issue7
dc.description.page3613-3626
dc.description.codenCSRVB
dc.identifier.isiut000291807600017
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