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Title: Synthesis of Heterocyclic Analogues of Tamoxifen as Potential Antiestrogens
Authors: Srikanth, N. 
Tan, C.-H. 
Ng, S.-C. 
Loh, T.-P. 
Koh, L.-L. 
Sim, K.-Y. 
Issue Date: 1997
Citation: Srikanth, N.,Tan, C.-H.,Ng, S.-C.,Loh, T.-P.,Koh, L.-L.,Sim, K.-Y. (1997). Synthesis of Heterocyclic Analogues of Tamoxifen as Potential Antiestrogens. Journal of Chemical Research - Part S (8) : 274-275. ScholarBank@NUS Repository.
Abstract: The synthesis of (E/Z)-1-aryl-2-phenyl-1-(2-thienyI/selenophen-2-yl)but-1-enes, derived from 2- phenyl-1-(2-thienyl/ selenophen-2-y1)butan-1-ones, is described; the key steps in the synthesis involve the reaction of the butan-1-ones with 4-(2-morpholinoethoxy)phenyl bromide, followed by dehydration of the resulting carbinols to give the target compounds which are separated by fractional recrystallisation.
Source Title: Journal of Chemical Research - Part S
ISSN: 03082342
Appears in Collections:Staff Publications

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