Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging

Please use this identifier to cite or link to this item: https://doi.org/10.1039/c1ob05519d

Title:	Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging
Authors:	Vendrell, M. Samanta, A. Yun, S.-W. Chang, Y.-T.
Issue Date:	7-Jul-2011
Citation:	Vendrell, M., Samanta, A., Yun, S.-W., Chang, Y.-T. (2011-07-07). Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging. Organic and Biomolecular Chemistry 9 (13) : 4760-4762. ScholarBank@NUS Repository. https://doi.org/10.1039/c1ob05519d
Abstract:	We report the synthesis and characterization of a novel NIR fluorescent deoxyglucose analogue, CyNE 2-DG. Experiments in different cell lines showed a preferential uptake of CyNE 2-DG in cancer cells and its effective competition with unlabeled d-glucose. Cell imaging experiments demonstrated the superior cell-permeability of CyNE 2-DG over the NIR standard IRDye 800CW 2-DG, and validated its application for cancer cell imaging in the NIR region. © The Royal Society of Chemistry 2011.
Source Title:	Organic and Biomolecular Chemistry
URI:	http://scholarbank.nus.edu.sg/handle/10635/77129
ISSN:	14770520
DOI:	10.1039/c1ob05519d
Appears in Collections:	Staff Publications

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