Self-assembly of perfunctionalized β-cyclodextrins on a quartz crystal microbalance lor real-time chiral recognition

Abstract

This study reports the development of novel chiral sensors based on the self-assembly of perfunctionalized β-cyclodextrins (&beta-CD) on a quartz crystal microbalance transducer for real time chiral recognition. Ten chiral sensors immobilized with mercaptyl perfunctionalized β-cyclodextrins were found to exhibit promising enantioselectivity in the gas phase. Well-defined sizes of molecular cavities of the modified β-CDs associated with cooperative weak interactions with the host molecules afforded enhanced chiral discrimination. This study contributes to the realization of novel chiral sensors applicable for real-time recognition and analysis of enantiomeric alcohols and lactates. © 2008 American Chemical Society.