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Alternative Title
Abstract
The way to a 14-3-3 binder: A fragment-based combinatorial small-molecule microarray generates affinity-based fingerprints of the 14-3-3σ protein. One small molecule (see picture; in red box) that disrupts the 14-3-3/protein interaction (green/blue) has been identified. The compound is cell-permeable and possesses both in vitro and in-cell activities.© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keywords
Combinatorial chemistry, Fragment-based screening, Microarrays, Protein-protein interactions, Proteins
Source Title
Angewandte Chemie - International Edition
Publisher
Series/Report No.
Collections
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Date
2010-09-03
DOI
10.1002/anie.201003257
Type
Article