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https://doi.org/10.1002/anie.201003257
| Title: | Microarray-assisted high-throughput identification of a cell-permeable small-molecule binder of 14-3-3 proteins | Authors: | Wu, H. Ge, J. Yao, S.Q. |
Keywords: | Combinatorial chemistry Fragment-based screening Microarrays Protein-protein interactions Proteins |
Issue Date: | 3-Sep-2010 | Citation: | Wu, H., Ge, J., Yao, S.Q. (2010-09-03). Microarray-assisted high-throughput identification of a cell-permeable small-molecule binder of 14-3-3 proteins. Angewandte Chemie - International Edition 49 (37) : 6528-6532. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201003257 | Abstract: | The way to a 14-3-3 binder: A fragment-based combinatorial small-molecule microarray generates affinity-based fingerprints of the 14-3-3σ protein. One small molecule (see picture; in red box) that disrupts the 14-3-3/protein interaction (green/blue) has been identified. The compound is cell-permeable and possesses both in vitro and in-cell activities.© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. | Source Title: | Angewandte Chemie - International Edition | URI: | http://scholarbank.nus.edu.sg/handle/10635/76488 | ISSN: | 14337851 | DOI: | 10.1002/anie.201003257 |
| Appears in Collections: | Staff Publications |
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