Please use this identifier to cite or link to this item:
https://doi.org/10.1002/anie.201003257
| Title: | Microarray-assisted high-throughput identification of a cell-permeable small-molecule binder of 14-3-3 proteins | Authors: | Wu, H. Ge, J. Yao, S.Q. |
Keywords: | Combinatorial chemistry Fragment-based screening Microarrays Protein-protein interactions Proteins |
Issue Date: | 3-Sep-2010 | Citation: | Wu, H., Ge, J., Yao, S.Q. (2010-09-03). Microarray-assisted high-throughput identification of a cell-permeable small-molecule binder of 14-3-3 proteins. Angewandte Chemie - International Edition 49 (37) : 6528-6532. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201003257 | Abstract: | The way to a 14-3-3 binder: A fragment-based combinatorial small-molecule microarray generates affinity-based fingerprints of the 14-3-3σ protein. One small molecule (see picture; in red box) that disrupts the 14-3-3/protein interaction (green/blue) has been identified. The compound is cell-permeable and possesses both in vitro and in-cell activities.© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. | Source Title: | Angewandte Chemie - International Edition | URI: | http://scholarbank.nus.edu.sg/handle/10635/76488 | ISSN: | 14337851 | DOI: | 10.1002/anie.201003257 |
| Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
SCOPUSTM
Citations
71
checked on Jan 31, 2023
WEB OF SCIENCETM
Citations
68
checked on Jan 24, 2023
Page view(s)
157
checked on Jan 26, 2023
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.