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https://doi.org/10.1021/co400060b
| Title: | Fluorescent dye cocktail for multiplex drug-site mapping on human serum albumin | Authors: | Er, J.C. Vendrell, M. Tang, M.K. Zhai, D. Chang, Y.-T. |
Keywords: | drug discovery fluorescence high-throughput screening human serum albumin multiplex assays pharmacokinetics |
Issue Date: | 9-Sep-2013 | Citation: | Er, J.C., Vendrell, M., Tang, M.K., Zhai, D., Chang, Y.-T. (2013-09-09). Fluorescent dye cocktail for multiplex drug-site mapping on human serum albumin. ACS Combinatorial Science 15 (9) : 452-457. ScholarBank@NUS Repository. https://doi.org/10.1021/co400060b | Abstract: | Elucidating how molecules bind to HSA is fundamental for predicting drug incompatibilities. Through combinatorial screening, we identified a novel fluorescent dye (BD140) with turn-on fluorescence emission and specific binding at HSA drug site 2. We further combined it with dansylamide to develop a fluorescent dye cocktail for high-throughput mapping of the interaction between therapeutics at HSA drug-binding sites. © 2013 American Chemical Society. | Source Title: | ACS Combinatorial Science | URI: | http://scholarbank.nus.edu.sg/handle/10635/76195 | ISSN: | 21568952 | DOI: | 10.1021/co400060b |
| Appears in Collections: | Staff Publications |
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