Please use this identifier to cite or link to this item: https://doi.org/10.1021/co400060b
Title: Fluorescent dye cocktail for multiplex drug-site mapping on human serum albumin
Authors: Er, J.C.
Vendrell, M.
Tang, M.K.
Zhai, D.
Chang, Y.-T. 
Keywords: drug discovery
fluorescence
high-throughput screening
human serum albumin
multiplex assays
pharmacokinetics
Issue Date: 9-Sep-2013
Citation: Er, J.C., Vendrell, M., Tang, M.K., Zhai, D., Chang, Y.-T. (2013-09-09). Fluorescent dye cocktail for multiplex drug-site mapping on human serum albumin. ACS Combinatorial Science 15 (9) : 452-457. ScholarBank@NUS Repository. https://doi.org/10.1021/co400060b
Abstract: Elucidating how molecules bind to HSA is fundamental for predicting drug incompatibilities. Through combinatorial screening, we identified a novel fluorescent dye (BD140) with turn-on fluorescence emission and specific binding at HSA drug site 2. We further combined it with dansylamide to develop a fluorescent dye cocktail for high-throughput mapping of the interaction between therapeutics at HSA drug-binding sites. © 2013 American Chemical Society.
Source Title: ACS Combinatorial Science
URI: http://scholarbank.nus.edu.sg/handle/10635/76195
ISSN: 21568952
DOI: 10.1021/co400060b
Appears in Collections:Staff Publications

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