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|Title:||Fluorescent dye cocktail for multiplex drug-site mapping on human serum albumin|
human serum albumin
|Citation:||Er, J.C., Vendrell, M., Tang, M.K., Zhai, D., Chang, Y.-T. (2013-09-09). Fluorescent dye cocktail for multiplex drug-site mapping on human serum albumin. ACS Combinatorial Science 15 (9) : 452-457. ScholarBank@NUS Repository. https://doi.org/10.1021/co400060b|
|Abstract:||Elucidating how molecules bind to HSA is fundamental for predicting drug incompatibilities. Through combinatorial screening, we identified a novel fluorescent dye (BD140) with turn-on fluorescence emission and specific binding at HSA drug site 2. We further combined it with dansylamide to develop a fluorescent dye cocktail for high-throughput mapping of the interaction between therapeutics at HSA drug-binding sites. © 2013 American Chemical Society.|
|Source Title:||ACS Combinatorial Science|
|Appears in Collections:||Staff Publications|
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