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Title: Diversity-oriented fluorescence library approach for the discovery of sensors and probes
Authors: Lee, J.-S. 
Kim, Y.K. 
Vendrell, M.
Chang, Y.-T. 
Issue Date: 2009
Citation: Lee, J.-S., Kim, Y.K., Vendrell, M., Chang, Y.-T. (2009). Diversity-oriented fluorescence library approach for the discovery of sensors and probes. Molecular BioSystems 5 (5) : 411-421. ScholarBank@NUS Repository.
Abstract: Fluorescent small molecules have received considerable attention due to their potential for chemosensing and bioimaging. A conventional strategy for probe development is a target-oriented approach based on known molecular recognition mechanisms for individual analytes. However, sophisticated rational design does not always guarantee the applicability of probes in complex biological systems. Therefore the speed and the scope of sensor development has been limited. To overcome these limitations, diversity-oriented fluorescence library approaches have been applied to develop new fluorescent probes in the absence of knowledge about the target recognition mechanism. This review summarizes recent advances in fluorescent probe development facilitated by diversity-oriented library approaches. © The Royal Society of Chemistry 2009.
Source Title: Molecular BioSystems
ISSN: 1742206X
DOI: 10.1039/b821766c
Appears in Collections:Staff Publications

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