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Title: Click-based synthesis and proteomic profiling of lipstatin analogues
Authors: Ngai, M.H. 
Yang, P.-Y.
Liu, K.
Shen, Y. 
Wenk, M.R.
Yao, S.Q. 
Lear, M.J. 
Issue Date: 28-Nov-2010
Citation: Ngai, M.H., Yang, P.-Y., Liu, K., Shen, Y., Wenk, M.R., Yao, S.Q., Lear, M.J. (2010-11-28). Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications 46 (44) : 8335-8337. ScholarBank@NUS Repository.
Abstract: Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved ability to induce tumour cell death. © 2010 The Royal Society of Chemistry.
Source Title: Chemical Communications
ISSN: 13597345
DOI: 10.1039/c0cc01276a
Appears in Collections:Staff Publications

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