Click-based synthesis and proteomic profiling of lipstatin analogues

Please use this identifier to cite or link to this item: https://doi.org/10.1039/c0cc01276a

Title:	Click-based synthesis and proteomic profiling of lipstatin analogues
Authors:	Ngai, M.H. Yang, P.-Y. Liu, K. Shen, Y. Wenk, M.R. Yao, S.Q. Lear, M.J.
Issue Date:	28-Nov-2010
Citation:	Ngai, M.H., Yang, P.-Y., Liu, K., Shen, Y., Wenk, M.R., Yao, S.Q., Lear, M.J. (2010-11-28). Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications 46 (44) : 8335-8337. ScholarBank@NUS Repository. https://doi.org/10.1039/c0cc01276a
Abstract:	Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved ability to induce tumour cell death. © 2010 The Royal Society of Chemistry.
Source Title:	Chemical Communications
URI:	http://scholarbank.nus.edu.sg/handle/10635/75762
ISSN:	13597345
DOI:	10.1039/c0cc01276a
Appears in Collections:	Staff Publications

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