Please use this identifier to cite or link to this item: https://doi.org/10.1021/jf8028539
Title: Baicalin improves antioxidant status of streptozotocin-induced diabetic wistar rats
Authors: Waisundara, V.Y.
Hsu, A.
Tan, B.K.-H.
Huang, D. 
Keywords: Baicalin
Diabetes
Metformin
Oxidative stress
Streptozotocin
Issue Date: 27-May-2009
Citation: Waisundara, V.Y., Hsu, A., Tan, B.K.-H., Huang, D. (2009-05-27). Baicalin improves antioxidant status of streptozotocin-induced diabetic wistar rats. Journal of Agricultural and Food Chemistry 57 (10) : 4096-4102. ScholarBank@NUS Repository. https://doi.org/10.1021/jf8028539
Abstract: This study investigated the antioxidant and antidiabetic effects of baicalin, as well as its effects in combination with the antidiabetic drug metformin. Three groups of streptozotocin-induced diabetic rats were given the following treatments for 30 days: (1) 500 mg/kg metformin; (2) 120 mg/kg baicalin; (3) 500 mg/kg metformin + 120 mg/kg baicalin. In addition, vehicle-treated diabetic and nondiabetic controls were used in the experiment. The rats treated with baicalin and metformin + baicalin had significantly elevated (p < 0.05) hepatic activities of superoxide dismutase, catalase, and glutathione peroxidase compared with the vehicle- and metformin-treated groups. Plasma and hepatic lipid peroxide concentrations of the baicalin- and baicalin + metformin-treated groups were significantly reduced (p < 0.05). In addition, baicalin significantly reduced plasma and hepatic triglycerides and cholesterol levels. The study thus showed that baicalin mitigated oxidative stress as well as enhanced the antidiabetic effect of metformin by improving the antioxidant status. © 2009 American Chemical Society.
Source Title: Journal of Agricultural and Food Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/75639
ISSN: 00218561
DOI: 10.1021/jf8028539
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

28
checked on Jul 22, 2019

WEB OF SCIENCETM
Citations

28
checked on Jul 22, 2019

Page view(s)

65
checked on Jul 20, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.