Please use this identifier to cite or link to this item: https://doi.org/10.1021/jf8028539
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dc.titleBaicalin improves antioxidant status of streptozotocin-induced diabetic wistar rats
dc.contributor.authorWaisundara, V.Y.
dc.contributor.authorHsu, A.
dc.contributor.authorTan, B.K.-H.
dc.contributor.authorHuang, D.
dc.date.accessioned2014-06-23T05:32:49Z
dc.date.available2014-06-23T05:32:49Z
dc.date.issued2009-05-27
dc.identifier.citationWaisundara, V.Y., Hsu, A., Tan, B.K.-H., Huang, D. (2009-05-27). Baicalin improves antioxidant status of streptozotocin-induced diabetic wistar rats. Journal of Agricultural and Food Chemistry 57 (10) : 4096-4102. ScholarBank@NUS Repository. https://doi.org/10.1021/jf8028539
dc.identifier.issn00218561
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/75639
dc.description.abstractThis study investigated the antioxidant and antidiabetic effects of baicalin, as well as its effects in combination with the antidiabetic drug metformin. Three groups of streptozotocin-induced diabetic rats were given the following treatments for 30 days: (1) 500 mg/kg metformin; (2) 120 mg/kg baicalin; (3) 500 mg/kg metformin + 120 mg/kg baicalin. In addition, vehicle-treated diabetic and nondiabetic controls were used in the experiment. The rats treated with baicalin and metformin + baicalin had significantly elevated (p < 0.05) hepatic activities of superoxide dismutase, catalase, and glutathione peroxidase compared with the vehicle- and metformin-treated groups. Plasma and hepatic lipid peroxide concentrations of the baicalin- and baicalin + metformin-treated groups were significantly reduced (p < 0.05). In addition, baicalin significantly reduced plasma and hepatic triglycerides and cholesterol levels. The study thus showed that baicalin mitigated oxidative stress as well as enhanced the antidiabetic effect of metformin by improving the antioxidant status. © 2009 American Chemical Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/jf8028539
dc.sourceScopus
dc.subjectBaicalin
dc.subjectDiabetes
dc.subjectMetformin
dc.subjectOxidative stress
dc.subjectStreptozotocin
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1021/jf8028539
dc.description.sourcetitleJournal of Agricultural and Food Chemistry
dc.description.volume57
dc.description.issue10
dc.description.page4096-4102
dc.description.codenJAFCA
dc.identifier.isiut000266237800017
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