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|Title:||Application of lipid as emulsifier in the solvent evaporation technique in fabrication of polymeric nanospheres for controlled release of Taxol®||Authors:||Huang, G.
|Issue Date:||2000||Citation:||Huang, G.,Feng, S. (2000). Application of lipid as emulsifier in the solvent evaporation technique in fabrication of polymeric nanospheres for controlled release of Taxol®. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings 3 : 2102-2105. ScholarBank@NUS Repository.||Abstract:||This study was intended to examine the potential of Application of 1,2-dipalmitoylphosphatidylcholine (DPPC) as an emulsifier in the solvent evaporation technique, which is one of the most widely used methods to prepare polymeric microspheres and nanospheres for controlled release of an effective anticancer drug Paclitaxel (Taxol®). The poly(D, L-lactic-co-glycolic acid) (PLGA, 75/25) nanospheres loaded with Taxol were prepared by the solvent evaporation technique wit DPPC and/or poly (vinyl alcohol) (PVA) as emulsifier(s). The fabricated nanospheres in various conditions were characterized by Scanning Electron Microscopy (SEM) and Laser Light Scattering, which revealed that the size of nanospheres ranged from 400nm to 900nm. The encapsulation efficiency was measured by High Performance Liquid Chromatography (HPLC). The result showed that nanospheres fabricated with DPPC as emulsifier have higher encapsulation efficiency (EE) than those with PVA. It was also demonstrated that the EE of nanospheres fabricated with both DPPC and PVA as emulsifiers is higher than those of nanospheres with DPPC or PVA as emulsifier alone, which suggested that a synergetic effect may exist between PVA and DPPC. The surface property of nanospheres containing DPPC was also studied by X-ray Photoelectron Spectra (XPS), which showed a dominance of DPPC on the nanospheres surface. XPS study and the in vitro release experiment suggest that nanospheres fabricated with DPPC can be an improved drug delivery system.||Source Title:||Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings||URI:||http://scholarbank.nus.edu.sg/handle/10635/75184||ISSN:||05891019|
|Appears in Collections:||Staff Publications|
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