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Title: Immobilized hepatocyte spheroids on galactose ligand-conjugated nanofiber scaffold
Authors: Chua, K.N.
Lim, W.S.
Lu, H.F.
Chai, C.
Zhang, P.C.
Wen, J.
Ramakrishna, S. 
Leong, K.W.
Mao, H.Q.
Issue Date: 2004
Citation: Chua, K.N.,Lim, W.S.,Lu, H.F.,Chai, C.,Zhang, P.C.,Wen, J.,Ramakrishna, S.,Leong, K.W.,Mao, H.Q. (2004). Immobilized hepatocyte spheroids on galactose ligand-conjugated nanofiber scaffold. Transactions - 7th World Biomaterials Congress : 1753-. ScholarBank@NUS Repository.
Abstract: The effect of nanofiber scaffold on hepatocyte attachment, migration, spheroid formation and maintenance if the differentiated functions was analyzed. A hepatocyte specific nanofiber scaffold was synthesized by conjugating 1-O-(6'-aminohexyl)-D-galactopyranoside (AHG) galactose ligands to the poly(acrylic acid) grafted polycaprolactone (PCL)-co- ethylethylene phosphate (EEP) nanofiber mesh. It was found that hepatocytes cultured on galactosylated PCL-co-EEP nanofiber scaffolds and thin film substrates exhibited similarly high hepatocyte attachment (~80-90%). The results show that the nanofiber scaffolds exhibits unique properties of promoting hepatocyte aggregates within the spaces and around the fiber.
Source Title: Transactions - 7th World Biomaterials Congress
ISBN: 1877040193
Appears in Collections:Staff Publications

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