Please use this identifier to cite or link to this item:
|Title:||Immobilized hepatocyte spheroids on galactose ligand-conjugated nanofiber scaffold|
|Citation:||Chua, K.N.,Lim, W.S.,Lu, H.F.,Chai, C.,Zhang, P.C.,Wen, J.,Ramakrishna, S.,Leong, K.W.,Mao, H.Q. (2004). Immobilized hepatocyte spheroids on galactose ligand-conjugated nanofiber scaffold. Transactions - 7th World Biomaterials Congress : 1753-. ScholarBank@NUS Repository.|
|Abstract:||The effect of nanofiber scaffold on hepatocyte attachment, migration, spheroid formation and maintenance if the differentiated functions was analyzed. A hepatocyte specific nanofiber scaffold was synthesized by conjugating 1-O-(6'-aminohexyl)-D-galactopyranoside (AHG) galactose ligands to the poly(acrylic acid) grafted polycaprolactone (PCL)-co- ethylethylene phosphate (EEP) nanofiber mesh. It was found that hepatocytes cultured on galactosylated PCL-co-EEP nanofiber scaffolds and thin film substrates exhibited similarly high hepatocyte attachment (~80-90%). The results show that the nanofiber scaffolds exhibits unique properties of promoting hepatocyte aggregates within the spaces and around the fiber.|
|Source Title:||Transactions - 7th World Biomaterials Congress|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 2, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.