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Title: Modeling cell entry into a micro-channel
Authors: Leong, F.Y.
Li, Q. 
Lim, C.T. 
Chiam, K.-H.
Keywords: Cell entry
Cell sorting
Immersed boundary method
Issue Date: Oct-2011
Citation: Leong, F.Y., Li, Q., Lim, C.T., Chiam, K.-H. (2011-10). Modeling cell entry into a micro-channel. Biomechanics and Modeling in Mechanobiology 10 (5) : 755-766. ScholarBank@NUS Repository.
Abstract: Cell entry into a micro-channel has potential applications in cell sorting and cancer diagnostics. In this paper, we numerically model breast cancer cell entry into a constricted micro-channel. Our results indicate that the cell velocity decreases during entry and increases after entry, an observation in agreement with experiments. We found that the cell entry time depend strongly on the cortical stiffness and is minimum at some critical cortical elasticity. In addition, we found that for the same entry time, a stiff nucleus is displaced toward the cell front, whereas a viscous nucleus is displaced toward the rear. In comparison, the nucleus is less sensitive to the viscosity of the cytoplasm. These observations suggest that specific intra-cellular properties can be deduced non-invasively during cell entry, through the inspection of the nucleus using suitable illumination techniques, such as fluorescent labeling. © Springer-Verlag 2010.
Source Title: Biomechanics and Modeling in Mechanobiology
ISSN: 16177959
DOI: 10.1007/s10237-010-0271-1
Appears in Collections:Staff Publications

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