Please use this identifier to cite or link to this item:
|Title:||Modeling cell entry into a micro-channel|
Immersed boundary method
|Citation:||Leong, F.Y., Li, Q., Lim, C.T., Chiam, K.-H. (2011-10). Modeling cell entry into a micro-channel. Biomechanics and Modeling in Mechanobiology 10 (5) : 755-766. ScholarBank@NUS Repository. https://doi.org/10.1007/s10237-010-0271-1|
|Abstract:||Cell entry into a micro-channel has potential applications in cell sorting and cancer diagnostics. In this paper, we numerically model breast cancer cell entry into a constricted micro-channel. Our results indicate that the cell velocity decreases during entry and increases after entry, an observation in agreement with experiments. We found that the cell entry time depend strongly on the cortical stiffness and is minimum at some critical cortical elasticity. In addition, we found that for the same entry time, a stiff nucleus is displaced toward the cell front, whereas a viscous nucleus is displaced toward the rear. In comparison, the nucleus is less sensitive to the viscosity of the cytoplasm. These observations suggest that specific intra-cellular properties can be deduced non-invasively during cell entry, through the inspection of the nucleus using suitable illumination techniques, such as fluorescent labeling. © Springer-Verlag 2010.|
|Source Title:||Biomechanics and Modeling in Mechanobiology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on May 17, 2018
WEB OF SCIENCETM
checked on May 9, 2018
checked on Apr 20, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.