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|Title:||Enantiomer separation of flavour and fragrance compounds by liquid chromatography using novel urea-covalent bonded methylated β-cyclodextrins on silica||Authors:||Ng, S.-C.
Chiral stationary phases, LC
|Issue Date:||30-Aug-2002||Citation:||Ng, S.-C., Ong, T.-T., Fu, P., Ching, C.-B. (2002-08-30). Enantiomer separation of flavour and fragrance compounds by liquid chromatography using novel urea-covalent bonded methylated β-cyclodextrins on silica. Journal of Chromatography A 968 (1-2) : 31-40. ScholarBank@NUS Repository. https://doi.org/10.1016/S0021-9673(02)00840-3||Abstract:||A novel methylated β-cyclodextrin chiral stationary phase (CSP-ME), which was chemically immobilised onto porous silica via multiple urea-linkages was synthesised. The CSP-ME chiral stationary phase depicted good enantiomer separation abilities for some well-known flavour as well as fragrance compounds using high-performance liquid chromatography under reverse phase conditions. The optimum resolution for α-ionone, 3-methyl-α-ionone, flavanone, 5-methoxyflavanone, 6-methoxyflavanone, 7-methoxyflavanone, hesperetin, naringenin and taxifolin was achieved using a mobile phase composition consisting of 1 wt.% triethylammonium acetate buffer (pH 4.68)-methanol. The effects of pH of triethylammonium acetate buffer and the methanol-acetonitrile content of the mobile phase composition on their retention time and resolution were examined to optimise the separation conditions. © 2002 Elsevier Science B.V. All rights reserved.||Source Title:||Journal of Chromatography A||URI:||http://scholarbank.nus.edu.sg/handle/10635/66580||ISSN:||00219673||DOI:||10.1016/S0021-9673(02)00840-3|
|Appears in Collections:||Staff Publications|
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