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|Title:||Enantiomer separation of flavour and fragrance compounds by liquid chromatography using novel urea-covalent bonded methylated β-cyclodextrins on silica|
|Authors:||Ng, S.-C. |
Chiral stationary phases, LC
|Source:||Ng, S.-C.,Ong, T.-T.,Fu, P.,Ching, C.-B. (2002-08-30). Enantiomer separation of flavour and fragrance compounds by liquid chromatography using novel urea-covalent bonded methylated β-cyclodextrins on silica. Journal of Chromatography A 968 (1-2) : 31-40. ScholarBank@NUS Repository. https://doi.org/10.1016/S0021-9673(02)00840-3|
|Abstract:||A novel methylated β-cyclodextrin chiral stationary phase (CSP-ME), which was chemically immobilised onto porous silica via multiple urea-linkages was synthesised. The CSP-ME chiral stationary phase depicted good enantiomer separation abilities for some well-known flavour as well as fragrance compounds using high-performance liquid chromatography under reverse phase conditions. The optimum resolution for α-ionone, 3-methyl-α-ionone, flavanone, 5-methoxyflavanone, 6-methoxyflavanone, 7-methoxyflavanone, hesperetin, naringenin and taxifolin was achieved using a mobile phase composition consisting of 1 wt.% triethylammonium acetate buffer (pH 4.68)-methanol. The effects of pH of triethylammonium acetate buffer and the methanol-acetonitrile content of the mobile phase composition on their retention time and resolution were examined to optimise the separation conditions. © 2002 Elsevier Science B.V. All rights reserved.|
|Source Title:||Journal of Chromatography A|
|Appears in Collections:||Staff Publications|
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