Please use this identifier to cite or link to this item:<467
Title: Biocompatibility of electroactive polymers in tissues
Authors: Kamalesh, S.
Tan, P.
Wang, J. 
Lee, T.
Kang, E.-T. 
Wang, C.-H. 
Keywords: Biocompatibility
Conductive polymer
Interstitial pressure
Issue Date: 2000
Citation: Kamalesh, S.,Tan, P.,Wang, J.,Lee, T.,Kang, E.-T.,Wang, C.-H. (2000). Biocompatibility of electroactive polymers in tissues. Journal of Biomedical Materials Research 52 (3) : 467-478. ScholarBank@NUS Repository.<467
Abstract: The biocompatibility of ethylene-vinyl acetate copolymer (EVAc), polyethylene (PE), and polyaniline (PANi) films in the emeraldine (EM), nigraniline (NA) and leucoemeraldine (LM) intrinsic oxidation states were assessed through subcutaneous implantation into male Sprague-Dawley rats beneath the dorsal skin, for a period ranging from 19 to 90 weeks. Histological examination, interstitial pressure measurement, and X-ray photoelectron spectroscopy (XPS) were employed to determine the biocompatibility of the polymers. The polymers did not provoke inflammatory responses in the subcutaneous tissues over the entire implantation period. Characteristics features associated with tissue-implant incompatibility were not evident near the implantation. Interstitial pressure was measured to evaluate the development of tissue. Low interstitial pressure readings on the region of implantation confirmed the biocompatibility of these polymer types. The surface composition of the electroactive aniline polymers before and after the implantation was characterized by XPS. (C) 2000 John Wiley and Sons, Inc.
Source Title: Journal of Biomedical Materials Research
ISSN: 00219304
DOI: 10.1002/1097-4636(20001205)52:3<467
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