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Title: Surface-active and stimuli-responsive polymer-Si(100) hybrids from surface-initiated atom transfer radical polymerization for control of cell adhesion
Authors: Xu, F.J. 
Zhong, S.P. 
Yung, L.Y.L. 
Kang, E.T. 
Neoh, K.G. 
Issue Date: Nov-2004
Citation: Xu, F.J., Zhong, S.P., Yung, L.Y.L., Kang, E.T., Neoh, K.G. (2004-11). Surface-active and stimuli-responsive polymer-Si(100) hybrids from surface-initiated atom transfer radical polymerization for control of cell adhesion. Biomacromolecules 5 (6) : 2392-2403. ScholarBank@NUS Repository.
Abstract: A simple two-step method was developed for the covalent immobilization of atom-transfer radical polymerization (ATRP) initiators on the hydrogen-terminated Si(100) (Si-H) surface. Well-defined functional polymer-Si hybrids, consisting of covalently tethered brushes of poly(ethylene glycol) monomethacrylate (PEGMA) polymer, N-isopropylacrylamide (NIPAAm) polymer, and NIPAAm-PEGMA copolymers and block copolymers on Si-H surfaces, were prepared via surface-initiated ATRP. Kinetics study revealed that the chain growth from the silicon surface was consistent with a "controlled" process. Surface cultures of the cell line 3T3-Swiss albino on the hybrids were evaluated. The PEGMA graft-polymerized silicon [Si-g-P(PEGMA)] surface is very effective in preventing cell attachment and growth. At 37 °C [above the lower critical solution temperature (LCST, ∼32 °C) of NIPAAm], the seeded cells adhered, spread, and proliferated on the NIPAAm graft polymerized silicon [Si-g-P(NIPAAm)] surface. Below the LCST, the cells detached from the Si-g-P(NIPAAm) surface spontaneously. Incorporation of PEGMA units into the NIPAAm chains of the Si-g-P(NIPAAm surface via copolymerization resulted in more rapid cell detachment during the temperature transition. The "active" chain ends on the Si-g-P(PEGMA) and Si-g-P(NIPAAm) hybrids were also used as the macroinitiators for the synthesis of diblock copolymer brushes. Thus, not only are the hybrids potentially useful as stimuli-responsive adhesion modifiers for cells in silicon-based biomedical microdevices but also the active chain ends on the hybrid surfaces offer opportunities for further surface functionalization and molecular design. © 2004 American Chemical Society.
Source Title: Biomacromolecules
ISSN: 15257797
DOI: 10.1021/bm049675a
Appears in Collections:Staff Publications

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