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|Title:||Drug permeation through temperature-sensitive membranes prepared from poly(vinylidene fluoride) with grafted poly(N-isopropylacrylamide) chains||Authors:||Ying, L.
|Issue Date:||1-Nov-2004||Citation:||Ying, L., Kang, E.T., Neoh, K.G., Kato, K., Iwata, H. (2004-11-01). Drug permeation through temperature-sensitive membranes prepared from poly(vinylidene fluoride) with grafted poly(N-isopropylacrylamide) chains. Journal of Membrane Science 243 (1-2) : 253-262. ScholarBank@NUS Repository. https://doi.org/10.1016/j.memsci.2004.06.028||Abstract:||Temperature-responsive copolymers, poly(vinylidene fluoride)-graft-poly(N- isopropylacrylamide) (PVDF-g-PNIPAAM), were synthesized by thermally-induced graft copolymerization of N-isopropylacrylamide (NIPAAM) with the ozone-pretreated PVDF. Temperature-sensitive microfiltration membranes were then prepared from the PVDF-g-PNIPAAM copolymers by phase inversion. The chemical structure and composition of the PVDF-g-PNIPAAM copolymers were characterized by FT-IR spectroscopy and elemental analysis. X-ray photoelectron spectroscopy (XPS) analyses of the membranes revealed a substantial surface enrichment in grafted NIPAAM polymer. The pore sizes of the PVDF-g-PNIPAAM membranes were measured using a Coulter® Porometer. The temperature-dependent swelling behavior of the membranes in aqueous solution was studied by atomic force microscope (AFM) and water retention behavior. Increasing the surface graft concentration of the membrane resulted in a higher degree of temperature-sensitive swelling. The copolymer membranes also exhibited reversible temperature-dependent permeability to calcein and fluorescein isothiocyanate (FITC)-dextran in phosphate buffer solutions (pH 7.4), with the most drastic change in permeability being observed in the temperature range between 27 and 32°C. © 2004 Elsevier B.V. All rights reserved.||Source Title:||Journal of Membrane Science||URI:||http://scholarbank.nus.edu.sg/handle/10635/63750||ISSN:||03767388||DOI:||10.1016/j.memsci.2004.06.028|
|Appears in Collections:||Staff Publications|
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