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Title: Antibacterial poly(D,L-lactide) (PDLLA) fibrous membranes modified with quaternary ammonium moieties
Authors: Yao, C.
Li, X.-S.
Neoh, K.G. 
Shi, Z.-L. 
Kang, E.T. 
Keywords: Antibacterial
Surface modification
Issue Date: Jul-2010
Citation: Yao, C., Li, X.-S., Neoh, K.G., Shi, Z.-L., Kang, E.T. (2010-07). Antibacterial poly(D,L-lactide) (PDLLA) fibrous membranes modified with quaternary ammonium moieties. Chinese Journal of Polymer Science (English Edition) 28 (4) : 581-588. ScholarBank@NUS Repository.
Abstract: Antibacterial poly(D,L-lactide) (PDLLA) fibrous membranes were developed via electrospinning, followed by surface modification which involved plasma pretreatment, UV-induced graft copolymerization of 4-vinylpyridine (4VP) and quaternization of the grafted pyridine groups with hexylbromide. The success of modification with quaternized pyridinium groups on the PDLLA fibrous membranes was ascertained by X-ray photoelectron spectroscopy (XPS). The antibacterial activities of these membranes were assessed against Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli). The PDLLA fibrous membranes modified with quaternized pyridinium groups showed antibacterial efficiency against both bacteria as high as 99.999%. The results demonstrated that the antibacterial activity was based on the interaction of the positive charge of pyridinium group and negatively charged cell membrane of bacteria, resulting in loss of membrane permeability and cell leakage. © 2010 Chinese Chemical Society, Institute of Chemistry, Chinese Academy of Sciences and Springer-Verlag Berlin Heidelberg.
Source Title: Chinese Journal of Polymer Science (English Edition)
ISSN: 02567679
DOI: 10.1007/s10118-010-9094-x
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