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Title: Electrospun biocomposite nanofibrous patch for cardiac tissue engineering
Authors: Prabhakaran, M.P. 
Kai, D.
Ghasemi-Mobarakeh, L.
Ramakrishna, S. 
Issue Date: Oct-2011
Citation: Prabhakaran, M.P., Kai, D., Ghasemi-Mobarakeh, L., Ramakrishna, S. (2011-10). Electrospun biocomposite nanofibrous patch for cardiac tissue engineering. Biomedical Materials 6 (5) : -. ScholarBank@NUS Repository.
Abstract: A bioengineered construct that matches the chemical, mechanical, biological properties and extracellular matrix morphology of native tissue could be suitable as a cardiac patch for supporting the heart after myocardial infarction. The potential of utilizing a composite nanofibrous scaffold of poly(dl-lactide-co-glycolide)/gelatin (PLGA/Gel) as a biomimetic cardiac patch is studied by culturing a population of cardiomyocyte containing cells on the electrospun scaffolds. The chemical characterization and mechanical properties of the electrospun PLGA and PLGA/Gel nanofibers were studied by Fourier transform infrared spectroscopy, scanning electron microscopy and tensile measurements. The biocompatibility of the scaffolds was also studied and the cardiomyocytes seeded on PLGA/Gel nanofibers were found to express the typical functional cardiac proteins such as alpha-actinin and troponin I, showing the easy integration of cardiomyocytes on PLGA/Gel scaffolds. Our studies strengthen the application of electrospun PLGA/Gel nanofibers as a bio-mechanical support for injured myocardium and as a potential substrate for induction of endogenous cardiomyocyte proliferation, ultimately reducing the cardiac dysfunction and improving cardiac remodeling. © 2011 IOP Publishing Ltd.
Source Title: Biomedical Materials
ISSN: 17486041
DOI: 10.1088/1748-6041/6/5/055001
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