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|Title:||Electrospun biocomposite nanofibrous patch for cardiac tissue engineering|
|Authors:||Prabhakaran, M.P. |
|Citation:||Prabhakaran, M.P., Kai, D., Ghasemi-Mobarakeh, L., Ramakrishna, S. (2011-10). Electrospun biocomposite nanofibrous patch for cardiac tissue engineering. Biomedical Materials 6 (5) : -. ScholarBank@NUS Repository. https://doi.org/10.1088/1748-6041/6/5/055001|
|Abstract:||A bioengineered construct that matches the chemical, mechanical, biological properties and extracellular matrix morphology of native tissue could be suitable as a cardiac patch for supporting the heart after myocardial infarction. The potential of utilizing a composite nanofibrous scaffold of poly(dl-lactide-co-glycolide)/gelatin (PLGA/Gel) as a biomimetic cardiac patch is studied by culturing a population of cardiomyocyte containing cells on the electrospun scaffolds. The chemical characterization and mechanical properties of the electrospun PLGA and PLGA/Gel nanofibers were studied by Fourier transform infrared spectroscopy, scanning electron microscopy and tensile measurements. The biocompatibility of the scaffolds was also studied and the cardiomyocytes seeded on PLGA/Gel nanofibers were found to express the typical functional cardiac proteins such as alpha-actinin and troponin I, showing the easy integration of cardiomyocytes on PLGA/Gel scaffolds. Our studies strengthen the application of electrospun PLGA/Gel nanofibers as a bio-mechanical support for injured myocardium and as a potential substrate for induction of endogenous cardiomyocyte proliferation, ultimately reducing the cardiac dysfunction and improving cardiac remodeling. © 2011 IOP Publishing Ltd.|
|Source Title:||Biomedical Materials|
|Appears in Collections:||Staff Publications|
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