Please use this identifier to cite or link to this item:
|Title:||Electrospun biocomposite nanofibrous patch for cardiac tissue engineering|
|Authors:||Prabhakaran, M.P. |
|Citation:||Prabhakaran, M.P., Kai, D., Ghasemi-Mobarakeh, L., Ramakrishna, S. (2011-10). Electrospun biocomposite nanofibrous patch for cardiac tissue engineering. Biomedical Materials 6 (5) : -. ScholarBank@NUS Repository. https://doi.org/10.1088/1748-6041/6/5/055001|
|Abstract:||A bioengineered construct that matches the chemical, mechanical, biological properties and extracellular matrix morphology of native tissue could be suitable as a cardiac patch for supporting the heart after myocardial infarction. The potential of utilizing a composite nanofibrous scaffold of poly(dl-lactide-co-glycolide)/gelatin (PLGA/Gel) as a biomimetic cardiac patch is studied by culturing a population of cardiomyocyte containing cells on the electrospun scaffolds. The chemical characterization and mechanical properties of the electrospun PLGA and PLGA/Gel nanofibers were studied by Fourier transform infrared spectroscopy, scanning electron microscopy and tensile measurements. The biocompatibility of the scaffolds was also studied and the cardiomyocytes seeded on PLGA/Gel nanofibers were found to express the typical functional cardiac proteins such as alpha-actinin and troponin I, showing the easy integration of cardiomyocytes on PLGA/Gel scaffolds. Our studies strengthen the application of electrospun PLGA/Gel nanofibers as a bio-mechanical support for injured myocardium and as a potential substrate for induction of endogenous cardiomyocyte proliferation, ultimately reducing the cardiac dysfunction and improving cardiac remodeling. © 2011 IOP Publishing Ltd.|
|Source Title:||Biomedical Materials|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 17, 2019
WEB OF SCIENCETM
checked on Mar 6, 2019
checked on Jan 26, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.