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|Title:||Long-term safety and efficacy are observed after implantation of Zotarolimus-Eluting stent in real-world clinical practice.||Authors:||Lee, C.H.
|Issue Date:||Nov-2008||Citation:||Lee, C.H.,Low, A.F.,Hong, E.C.,Tai, B.C.,Lim, I.H.,Teo, S.G.,Lim, Y.T.,Tan, H.C. (2008-11). Long-term safety and efficacy are observed after implantation of Zotarolimus-Eluting stent in real-world clinical practice.. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 4 (3) : 338-344. ScholarBank@NUS Repository.||Abstract:||AIMS: Zotarolimus-eluting stents (ZESs) have been shown to be safe and effective in randomised trials. We sought to report the clinical outcomes after implantation of ZES in real-world clinical practice. METHODS AND RESULTS: ZES have been approved for clinical use in Singapore since April 2005. Until December 31, 2007, a total of 219 patients had undergone implantation of ZES. After excluding 11 foreign patients with whom contact was lost, 208 patients (246 lesions, 305 stents) formed the study cohort. A high-proportion of diabetic patients (n=90, 43.3%) was included. Recommended dual antiplatelet therapy was at least 3 months (n=147) for patients treated before or 12 months (n=61) after January 2007. As of January 2008, the median follow-up duration was 19 months (range: 1 to 33 months). There were 10 (4.8%) deaths, including 7 (3.4%) cardiac deaths. Myocardial infarction occurred in 11 (5.3%) patients. The numbers of patients requiring target vessel revascularisation and target lesion revascularisation were 10 (4.8%) and 5 (2.4%) respectively. Using the ARC definition, there were two cases of definite stent thrombosis on days 7 and 17, and one case of probable stent thrombosis on day 15. CONCLUSIONS: In this real-world clinical experience, ZES was associated with a low incidence of adverse cardiac events at a medium follow-up of one and half years.||Source Title:||EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology||URI:||http://scholarbank.nus.edu.sg/handle/10635/53457||ISSN:||1774024X|
|Appears in Collections:||Staff Publications|
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