Please use this identifier to cite or link to this item:
|Title:||Increased iron staining in the cerebral cortex of cholesterol fed rabbits||Authors:||Ong, W.-Y.
|Issue Date:||Apr-2004||Citation:||Ong, W.-Y., Tan, B., Pan, N., Jenner, A., Whiteman, M., Ong, C.-N., Watt, F., Halliwell, B. (2004-04). Increased iron staining in the cerebral cortex of cholesterol fed rabbits. Mechanisms of Ageing and Development 125 (4) : 305-313. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mad.2004.01.008||Abstract:||The link between hypercholesterolemia and neuronal damage is not clear. In the present study, we studied some of the possible effects of hypercholesterolemia on the brain, using the cholesterol fed New Zealand White rabbit as a model. An increase in the number of iron positive cells (i.e. oligodendrocytes) was observed in the brain parenchyma, in rabbits treated with a high cholesterol diet for 8 weeks. At this time, no neuronal death was observed, indicating that the increased iron did not occur as a consequence of neuronal injury. No heme oxygenase-1 (HO-1) or bilirubin immunoreactivity was observed in the brains in these rabbits, indicating that the iron accumulation did not occur as a consequence of increased breakdown of heme. It is postulated that cholesterol could have subtly damaged brain endothelial cells, resulting in increased iron transport across brain endothelial cells. Hypercholesterolaemia is known to be associated with increased plasma lipid peroxidation which might contribute to such damage. © 2004 Elsevier Ireland Ltd. All rights reserved.||Source Title:||Mechanisms of Ageing and Development||URI:||http://scholarbank.nus.edu.sg/handle/10635/53294||ISSN:||00476374||DOI:||10.1016/j.mad.2004.01.008|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 15, 2021
WEB OF SCIENCETM
checked on Sep 30, 2021
checked on Oct 14, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.