Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.mad.2004.01.008
Title: Increased iron staining in the cerebral cortex of cholesterol fed rabbits
Authors: Ong, W.-Y.
Tan, B.
Pan, N. 
Jenner, A.
Whiteman, M.
Ong, C.-N. 
Watt, F. 
Halliwell, B.
Keywords: Atherosclerosis
Brain
Cholesterol
Hypercholesterolemia
Iron
Oligodendrocytes
Issue Date: Apr-2004
Source: Ong, W.-Y., Tan, B., Pan, N., Jenner, A., Whiteman, M., Ong, C.-N., Watt, F., Halliwell, B. (2004-04). Increased iron staining in the cerebral cortex of cholesterol fed rabbits. Mechanisms of Ageing and Development 125 (4) : 305-313. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mad.2004.01.008
Abstract: The link between hypercholesterolemia and neuronal damage is not clear. In the present study, we studied some of the possible effects of hypercholesterolemia on the brain, using the cholesterol fed New Zealand White rabbit as a model. An increase in the number of iron positive cells (i.e. oligodendrocytes) was observed in the brain parenchyma, in rabbits treated with a high cholesterol diet for 8 weeks. At this time, no neuronal death was observed, indicating that the increased iron did not occur as a consequence of neuronal injury. No heme oxygenase-1 (HO-1) or bilirubin immunoreactivity was observed in the brains in these rabbits, indicating that the iron accumulation did not occur as a consequence of increased breakdown of heme. It is postulated that cholesterol could have subtly damaged brain endothelial cells, resulting in increased iron transport across brain endothelial cells. Hypercholesterolaemia is known to be associated with increased plasma lipid peroxidation which might contribute to such damage. © 2004 Elsevier Ireland Ltd. All rights reserved.
Source Title: Mechanisms of Ageing and Development
URI: http://scholarbank.nus.edu.sg/handle/10635/53294
ISSN: 00476374
DOI: 10.1016/j.mad.2004.01.008
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