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Title: Zebrafish atonal homologue zath3 is expressed during neurogenesis in embryonic development
Authors: Wang, X.
Emelyanov, A.
Korzh, V. 
Gong, Z. 
Keywords: Acerebellar
Basic helix-loop-helix (bHLH)
No isthmus
Spiel ohne grensen
Issue Date: 1-Aug-2003
Citation: Wang, X., Emelyanov, A., Korzh, V., Gong, Z. (2003-08-01). Zebrafish atonal homologue zath3 is expressed during neurogenesis in embryonic development. Developmental Dynamics 227 (4) : 587-592. ScholarBank@NUS Repository.
Abstract: Basic helix-loop-helix (bHLH) transcriptional activators function in development of various cell lineages, including the central nervous system. One of the bHLH proteins, Math3/Xath3/NeuroM, was suggested to act as a late proneural gene in the mouse, Xenopus, and chick. Here, we isolated a zebrafish homologue, named zath3, and analyzed its expression pattern in zebrafish embryos. In the neural plate, zath3 is expressed first in the primordia of the tegmentum and trigeminal ganglia and three classes of primary neurons: sensory neurons, interneurons, and motor neurons. During later development, zath3 transcripts were localized along the boundaries of the optic tectum in the midbrain and rhombomeres of the hindbrain. Analyses of zath3 expression in three mid-hindbrain boundary mutants, acerebellar, no isthmus, and spiel-ohne-grensen, indicated that distribution of zath3 mRNAs in the midbrain and hindbrain was dramatically disturbed. In addition, these mutants also affect expression of zath3 in the neuroretina. © 2003 Wiley-Liss, Inc.
Source Title: Developmental Dynamics
ISSN: 10588388
DOI: 10.1002/dvdy.10331
Appears in Collections:Staff Publications

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