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Title: Risk factors for pandemic (H1N1) 2009 seroconversion among adults, Singapore, 2009
Authors: Lim, W.-Y. 
Chen, C.H.J.
Ma, Y.
Chen, M.I.C. 
Lee, V.J.M. 
Cook, A.R. 
Tan, L.W.L.
Tabo, N.F.
Barr, I.
Cui, L.
Lin, R.T.P.
Leo, Y.S.
Chia Jr., K.S. 
Issue Date: Aug-2011
Citation: Lim, W.-Y., Chen, C.H.J., Ma, Y., Chen, M.I.C., Lee, V.J.M., Cook, A.R., Tan, L.W.L., Tabo, N.F., Barr, I., Cui, L., Lin, R.T.P., Leo, Y.S., Chia Jr., K.S. (2011-08). Risk factors for pandemic (H1N1) 2009 seroconversion among adults, Singapore, 2009. Emerging Infectious Diseases 17 (8) : 1455-1462. ScholarBank@NUS Repository.
Abstract: A total of 828 community-dwelling adults were studied during the course of the pandemic (H1N1) 2009 outbreak in Singapore during June-September 2009. Baseline blood samples were obtained before the outbreak, and 2 additional samples were obtained during follow-up. Seroconversion was defined as a ≥4-fold increase in antibody titers to pandemic (H1N1) 2009, determined by using hemagglutination inhibition. Men were more likely than women to seroconvert (mean adjusted hazards ratio [HR] 2.23, mean 95% confidence interval [CI] 1.26-3.93); Malays were more likely than Chinese to seroconvert (HR 2.67, 95% CI 1.04-6.91). Travel outside Singapore during the study period was associated with seroconversion (HR 1.76, 95% CI 1.11-2.78) as was use of public transport (HR 1.81, 95% CI 1.05-3.09). High baseline antibody titers were associated with reduced seroconversion. This study suggests possible areas for intervention to reduce transmission during future influenza outbreaks.
Source Title: Emerging Infectious Diseases
ISSN: 10806040
DOI: 10.3201/eid1708.101270
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