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Title: Kinetics and template nucleation of self-assembled hydroxyapatite nanocrystallites by chondroitin sulfate
Authors: Jiang, H. 
Liu, X.-Y. 
Zhang, G. 
Li, Y.
Issue Date: 23-Dec-2005
Citation: Jiang, H., Liu, X.-Y., Zhang, G., Li, Y. (2005-12-23). Kinetics and template nucleation of self-assembled hydroxyapatite nanocrystallites by chondroitin sulfate. Journal of Biological Chemistry 280 (51) : 42061-42066. ScholarBank@NUS Repository.
Abstract: Biomineralization is an important process, which is often assisted by biomolecules. In this paper, the effect of chondroitin sulfate on the crystallization of hydroxyapatite was examined quantitatively based on a generic heterogeneous nucleation model. It is found that chondroitin sulfate can suppress the supersaturation-driven interfacial structure mismatch between the hydroxyapatite crystal and the substrate and promote the formation of ordered hydroxyapatite nanocrystallite assemblies. The nucleation mechanism of self-aligned hydroxyapatite nanocrystallites was examined from the viewpoints of kinetics and interfacial structure and properties, which contributes to an understanding of the fundamentals of biomineralization of self-assembled structures. The results obtained from this study will provide a basic principle to design and fabricate highly orderly organic-inorganic hybrid materials. © 2005 by The American Society for Biochemistry and Molecular Biology, Inc.
Source Title: Journal of Biological Chemistry
ISSN: 00219258
DOI: 10.1074/jbc.M412280200
Appears in Collections:Staff Publications

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