Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer
Ramachandran, L. Manu, K.A. Shanmugam, M.K. Li, F. Siveen, K.S. Vali, S. Kapoor, S. Abbasi, T. Surana, R. Smoot, D.T.
Ramachandran, L.
Li, F.
Siveen, K.S.
Vali, S.
Kapoor, S.
Abbasi, T.
Surana, R.
Smoot, D.T.
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Abstract
Background: PPAR-γ, a nuclear transcription factor, plays a critical role in the development of gastric cancer (GC). Hence, novel agents that can modulate PPAR-γ cascade have a great potential for the treatment of GC. Results: Isorhamnetin (IH) modulates PPAR-γ pathway in GC. Conclusion: IH induces apoptosis through the activation of the PPAR-γ pathway. Significance: The study proposes a novel agent for GC treatment. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.
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Journal of Biological Chemistry
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Date
2012-11-02
DOI
10.1074/jbc.M112.388702
Type
Article