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https://doi.org/10.1074/jbc.M112.388702
| Title: | Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer | Authors: | Ramachandran, L. Manu, K.A. Shanmugam, M.K. Li, F. Siveen, K.S. Vali, S. Kapoor, S. Abbasi, T. Surana, R. Smoot, D.T. Ashktorab, H. Tan, P. Ahn, K.S. Yap, C.W. Kumar, A.P. Sethi, G. |
Issue Date: | 2-Nov-2012 | Citation: | Ramachandran, L., Manu, K.A., Shanmugam, M.K., Li, F., Siveen, K.S., Vali, S., Kapoor, S., Abbasi, T., Surana, R., Smoot, D.T., Ashktorab, H., Tan, P., Ahn, K.S., Yap, C.W., Kumar, A.P., Sethi, G. (2012-11-02). Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer. Journal of Biological Chemistry 287 (45) : 38028-38040. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M112.388702 | Abstract: | Background: PPAR-γ, a nuclear transcription factor, plays a critical role in the development of gastric cancer (GC). Hence, novel agents that can modulate PPAR-γ cascade have a great potential for the treatment of GC. Results: Isorhamnetin (IH) modulates PPAR-γ pathway in GC. Conclusion: IH induces apoptosis through the activation of the PPAR-γ pathway. Significance: The study proposes a novel agent for GC treatment. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc. | Source Title: | Journal of Biological Chemistry | URI: | http://scholarbank.nus.edu.sg/handle/10635/53005 | ISSN: | 00219258 | DOI: | 10.1074/jbc.M112.388702 |
| Appears in Collections: | Staff Publications |
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