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Title: Development of vancomycin-capped β-CD-bonded silica particles as chiral stationary phase for LC
Authors: Zhao, J.
Thamarai Chelvi, S.K.
Tan, D.
Yong, E.L.
Lee, H.K. 
Gong, Y. 
Keywords: β-Cyclodextrin and vancomycin
Chiral separation
Chiral stationary phase
Column liquid chromatography
Issue Date: Dec-2010
Citation: Zhao, J., Thamarai Chelvi, S.K., Tan, D., Yong, E.L., Lee, H.K., Gong, Y. (2010-12). Development of vancomycin-capped β-CD-bonded silica particles as chiral stationary phase for LC. Chromatographia 72 (11-12) : 1061-1066. ScholarBank@NUS Repository.
Abstract: Vancomycin-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)- propylsilyl-appended silica particles (VCD-HPS), a new type of substituted β-cyclodextrin-bonded chiral stationary phase (CSP) for liquid chromatography (LC), have been synthesized by treatment of bromoacetate- substituted-(3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica particles (BACD-HPS) with vancomycin in anhydrous methanol. The stationary phase is characterized by elemental analysis. This new CSP has a chiral selector with two recognition sites: vancomycin and β-cyclodextrin (β-CD), which can provide multiple interactions with the solutes. The chromatographic performance of VCD-HPS was studied with several disubstituted benzenes and some chiral drug compounds as solutes in reversed-phase LC. The results show that VCD-HPS has excellent selectivity for the separation of aromatic positional isomers and enantiomers of chiral compounds. © 2010 Vieweg+Teubner Verlag | Springer Fachmedien Wiesbaden GmbH.
Source Title: Chromatographia
ISSN: 00095893
DOI: 10.1365/s10337-010-1788-2
Appears in Collections:Staff Publications

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