Please use this identifier to cite or link to this item: https://doi.org/10.1365/s10337-010-1788-2
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dc.titleDevelopment of vancomycin-capped β-CD-bonded silica particles as chiral stationary phase for LC
dc.contributor.authorZhao, J.
dc.contributor.authorThamarai Chelvi, S.K.
dc.contributor.authorTan, D.
dc.contributor.authorYong, E.L.
dc.contributor.authorLee, H.K.
dc.contributor.authorGong, Y.
dc.date.accessioned2014-05-19T02:51:12Z
dc.date.available2014-05-19T02:51:12Z
dc.date.issued2010-12
dc.identifier.citationZhao, J., Thamarai Chelvi, S.K., Tan, D., Yong, E.L., Lee, H.K., Gong, Y. (2010-12). Development of vancomycin-capped β-CD-bonded silica particles as chiral stationary phase for LC. Chromatographia 72 (11-12) : 1061-1066. ScholarBank@NUS Repository. https://doi.org/10.1365/s10337-010-1788-2
dc.identifier.issn00095893
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/52872
dc.description.abstractVancomycin-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)- propylsilyl-appended silica particles (VCD-HPS), a new type of substituted β-cyclodextrin-bonded chiral stationary phase (CSP) for liquid chromatography (LC), have been synthesized by treatment of bromoacetate- substituted-(3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica particles (BACD-HPS) with vancomycin in anhydrous methanol. The stationary phase is characterized by elemental analysis. This new CSP has a chiral selector with two recognition sites: vancomycin and β-cyclodextrin (β-CD), which can provide multiple interactions with the solutes. The chromatographic performance of VCD-HPS was studied with several disubstituted benzenes and some chiral drug compounds as solutes in reversed-phase LC. The results show that VCD-HPS has excellent selectivity for the separation of aromatic positional isomers and enantiomers of chiral compounds. © 2010 Vieweg+Teubner Verlag | Springer Fachmedien Wiesbaden GmbH.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1365/s10337-010-1788-2
dc.sourceScopus
dc.subjectβ-Cyclodextrin and vancomycin
dc.subjectChiral separation
dc.subjectChiral stationary phase
dc.subjectColumn liquid chromatography
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.description.doi10.1365/s10337-010-1788-2
dc.description.sourcetitleChromatographia
dc.description.volume72
dc.description.issue11-12
dc.description.page1061-1066
dc.description.codenCHRGB
dc.identifier.isiut000285099500006
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