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Title: Effects of nanofiber/stem cell composite on wound healing in acute full-thickness skin wounds
Authors: Ma, K.
Liao, S. 
He, L. 
Lu, J.
Ramakrishna, S. 
Chan, C.K. 
Issue Date: 1-May-2011
Citation: Ma, K., Liao, S., He, L., Lu, J., Ramakrishna, S., Chan, C.K. (2011-05-01). Effects of nanofiber/stem cell composite on wound healing in acute full-thickness skin wounds. Tissue Engineering - Part A 17 (9-10) : 1413-1424. ScholarBank@NUS Repository.
Abstract: Acute full-thickness skin wounds (FTSW) caused by extensive burns or high-energy trauma are not adequately addressed by current clinical treatments. This study hypothesized that biomimetic nanofiber scaffolds (NFSs) functionalized with rich attachment of bone-marrow-derived mesenchymal stem cells (BM-MSCs) can promote wound healing in acute FTSW. Results in a rat model showed that both NFS and BM-MSCs contributed to the wound healing. Wounds in NFS group with a higher density of BM-MSCs achieved complete closure 8 days earlier than the control group. Implanted BM-MSCs were found to promote epithelial edge ingrowth and collagen synthesis. The colocation of BM-MSCs (tagged with quantum-dots) with the expression of keratin 10 and filaggrin indicated the participation of BM-MSCs in epidermal differentiation at early and intermediate stages under the local wounding environment. Overall, this study suggests a great potential of using NFS/BM-MSC composites for the treatment of acute FTSW. © 2011 Mary Ann Liebert, Inc.
Source Title: Tissue Engineering - Part A
ISSN: 19373341
DOI: 10.1089/ten.tea.2010.0373
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