Please use this identifier to cite or link to this item:
|Title:||Effects of nanofiber/stem cell composite on wound healing in acute full-thickness skin wounds|
|Source:||Ma, K., Liao, S., He, L., Lu, J., Ramakrishna, S., Chan, C.K. (2011-05-01). Effects of nanofiber/stem cell composite on wound healing in acute full-thickness skin wounds. Tissue Engineering - Part A 17 (9-10) : 1413-1424. ScholarBank@NUS Repository. https://doi.org/10.1089/ten.tea.2010.0373|
|Abstract:||Acute full-thickness skin wounds (FTSW) caused by extensive burns or high-energy trauma are not adequately addressed by current clinical treatments. This study hypothesized that biomimetic nanofiber scaffolds (NFSs) functionalized with rich attachment of bone-marrow-derived mesenchymal stem cells (BM-MSCs) can promote wound healing in acute FTSW. Results in a rat model showed that both NFS and BM-MSCs contributed to the wound healing. Wounds in NFS group with a higher density of BM-MSCs achieved complete closure 8 days earlier than the control group. Implanted BM-MSCs were found to promote epithelial edge ingrowth and collagen synthesis. The colocation of BM-MSCs (tagged with quantum-dots) with the expression of keratin 10 and filaggrin indicated the participation of BM-MSCs in epidermal differentiation at early and intermediate stages under the local wounding environment. Overall, this study suggests a great potential of using NFS/BM-MSC composites for the treatment of acute FTSW. © 2011 Mary Ann Liebert, Inc.|
|Source Title:||Tissue Engineering - Part A|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 8, 2018
WEB OF SCIENCETM
checked on Feb 13, 2018
checked on Mar 12, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.